Hormone Replacement Therapy and Heartburn in WomenThe practice of augmenting estrogen and progesterone through hormone replacement therapy (HRT) to minimize menopause symptoms or increase estrogen levels after having a hysterectomy causes heartburn and acid reflux in women leading to increased risk of gastroesophageal reflux disease (GERD). GERD symptoms occur because postmenopausal hormones, selective estrogen receptor modulators, and over-the-counter hormone preparations aggravate heartburn and acid reflux by influencing gastrointestinal motility and relaxation of the lower esophageal sphincter (LES).


What is GERD?

GERD is the chronic occurrence of acid reflux and accounts for one of the most common medical conditions seen by primary care physicians accounting for significant medical costs.1,2,3 Studies show that up to 60% of people are affected by GERD in the course of a year and 20% to 30% are affected weekly.

Acid reflux occurs when the lower esophageal sphincter (LES), a ring of muscle at the base of the esophagus, fails to close properly allowing stomach acid to back up (reflux) into the esophagus to cause the pain we know as heartburn.3

Symptoms of GERD include:3,4

  • Heartburn
  • Bitter taste
  • Excessive saliva
  • Burping
  • Hiccups
  • Bloating
  • Laryngitis
  • Hoarseness
  • Cough
  • Nausea
  • Vomiting
  • Bloody stools or vomit
  • Asthma
  • Pneumonia
  • Sore throat
  • Dental erosion
  • Bad breath
  • Trouble swallowing
  • Weight loss


Hormone Replacement Therapy Increases the Risk of GERD Symptoms

Hormone replacement therapy minimizes menopausal symptoms and helps prevent bone loss due to the drop in estrogen levels. Studies, however, have found that postmenopausal hormones, selective estrogen receptor modulators, and over-the-counter hormone preparations are not only associated with cancer and cardiovascular disease5,6 but also an increase the risk of GERD.7,8 The risk of experiencing GERD symptoms increases when estrogen dose is increased along with the duration of use.8 Discontinuation of hormone replacement therapy shows a decreased in risk of GERD symptoms over time.

Hormone replacement therapy Causes a Higher Risk of GERD Symptoms as BMI Increases

Body mass plays a role in GERD. Weight in the abdominal region can cause added pressure on the stomach which in turn places pressure on and compromises the LES. The association between body mass and acid reflux is stronger in women than men. The association is especially prominent in premenopausal women, and use of hormone replacement therapy strengthens this association as body mass index (BMI) increases.9 These factors suggest that estrogen levels are a contributing factor in GERD… It’s also important to note that women taking estrogen gain more weight after menopause than women taking other categories of hormone replacement therapy.

Increased Estrogen Levels Result in the Relaxation of the LES Leading to Acid Reflux

Studies show that GERD symptoms increase whether estrogen and progesterone levels are elevated from internal or external sources. Relaxation of the LES occurs during pregnancy,10 with the sequential use of oral contraceptives11 and with the use of hormone replacement therapy.

Estrogen increases plasma nitric oxide levels,12 and nitric oxide causes smooth muscle relaxation. Smooth muscle relaxation causes the relaxation of the LES allowing stomach acid to reflux into the esophagus.13 Estrogen-only hormone replacement therapy causes higher plasma nitric oxide levels and has a stronger independent association with GERD symptoms than combined estrogen and progesterone therapy.14

Increased Risk GERD When taking NSAIDs and Tibolone

NSAIDs can irritate the esophageal lining causing heartburn and increase the severity of GERD or contribute to its development. The association between NSAIDs and GERD is higher with tibolone use than other hormone replacement therapy.15


Heartburn Prevention During Hormone Replacement Therapy

If hormone replacement therapy is used as a course of treatment, combined estrogen and progesterone hormone replacement therapy, as opposed to estrogen-only treatment, may help reduce the risk of GERD symptoms along with weight reduction.

Use of mucilage to help coat and protect the esophageal lining may be useful. Forms of mucilage to consider are:



Many women use hormone replacement therapy as an aid against the symptoms of menopause or to otherwise increase estrogen levels. Hormone replacement therapy can compromise the closure of the LES leading to chronic acid reflux and heartburn, a symptom of GERD.


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HowToTreatHeartburn.com is for informational purposes and should not be considered medical advice, diagnosis, or treatment recommendations. Please consult a physician to determine your best plan for treatment.

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